| Species reactivity | Human, Mouse, Rat, Acropora formosa, Aspergillus clavatus, Aspergillus fumigatus, Aspergillus niger, Aspergillus oryzae, Aspergillus terreus, Asterias rubens, Bos taurus, Botryotinia fuckeliana, Caenorhabditis elegans, Cairina moschata, Chaetomium globosum, Chironomus thummi thummi, Coccidioides immitis, Danio rerio, Drosophila erecta, Drosophila hydei, Drosophila melanogaster, Drosophila simulans, Drosophila yakuba, Emericella nidulans, Chicken, Gibberella zeae, Lytechinus pictus, Macaca fascicularis, Mytilus californianus, Mytilus chilensis, Mytilus edulis, Mytilus galloprovincialis, Mytilus trossulus, Neosartorya fischeri, Neurospora crassa, Oncorhynchus mykiss, Paracentrotus lividus, Parechinus angulosus, Penaeus vannamei, Phaeosphaeria nodorum, Platynereis dumerilii, Podospora anserina, Psammechinus miliaris, Pyricularia oryzae, Rhynchosciara americana, Sepia officinalis, Sipunculus nudus, Strongylocentrotus purpuratus, Tigriopus californicus, Urechis caupo, Xenopus laevis |
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| Target |
HIST1H2AB, Histone H2A.2, Histone H2A type 1-B/E, Histone H2A/m, HIST1H2AE, H2AFA, Histone H2A/a, H2AC4, H2AFM |
| Background | Histone H2A type 1-B/E (H2AC4) is a ~14 kDa protein. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
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