Anti-CD115/CSF1R Polyclonal Antibody (HY035014)

Name: Anti-CD115/CSF1R Polyclonal Antibody
Brand: abinScience
SKU: HY035014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HY035014

Description

Anti-CD115/CSF1R Polyclonal Antibody (HY035014) is a rabbit polyclonal antibody detecting CD115 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CD115/CSF1R (Ile20-Glu512).

Target

CD115, CSF-1 receptor, CSF1R, M-CSF-R, CSF-1-R, Proto-oncogene c-Fms, Macrophage colony-stimulating factor 1 receptor, CSF-1R, FMS

Purification

Purified by antigen affinity column.

Accession

P07333

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Macrophage colony-stimulating factor 1 receptor (CD115/CSF1R) is a ~107 kDa protein. Tyrosine-protein kinase that acts as a cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion.

1. Wei, S. et al. (2010) Journal of leukocyte biology 88, 495-505. PMID: 20504948

2. Guo, L. et al. (2019) American journal of human genetics 104, 925-935. PMID: 30982609

3. Oosterhof, N. et al. (2019) American journal of human genetics 104, 936-947. PMID: 30982608

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-CD115/CSF1R polyclonal antibody at 1ug/mL on recombinant CD115/CSF1R (Catalog No. HY035012).

References

Datasheet