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Anti-HEXB Polyclonal Antibody (HY435014)

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Overview
Catalog No.HY435014
Description
Anti-HEXB Polyclonal Antibody (HY435014) is a rabbit polyclonal antibody detecting HEXB in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human HEXB (Lys315-Tyr456).
Target N-Acetyl-β-glucosaminidase (NAG), chitobiase, NAG, Beta-hexosaminidase subunit beta, Beta-N-acetylhexosaminidase subunit beta, N-acetyl-beta-glucosaminidase subunit beta, Cervical cancer proto-oncogene 7 protein, Hexosaminidase subunit B, HCC-7, HEXB
Purification Purified by antigen affinity column.
Accession P07686
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Beta-hexosaminidase subunit beta (HEXB/HCC7) is a ~63 kDa protein. Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A. During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida.

1. Hepbildikler, ST. et al. (2002) The Journal of biological chemistry 277, 2562-72. PMID: 11707436
2. Novak, A. et al. (1994) Biochimica et biophysica acta 1199, 215-23. PMID: 8123671
3. Hou, Y. et al. (1996) Biochemistry 35, 3963-9. PMID: 8672428
4. Hou, Y. et al. (1998) The Journal of biological chemistry 273, 21386-92. PMID: 9694901
Note For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-HEXB Polyclonal Antibody

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