Anti-LYN Polyclonal Antibody (HY070014)

Name: Anti-LYN Polyclonal Antibody
Brand: abinScience
SKU: HY070014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

HY070014

Description

Anti-LYN Polyclonal Antibody (HY070014) is a rabbit polyclonal antibody detecting LYN in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human LYN (Met263-Asp491).

Target

Lck/Yes-related novel protein tyrosine kinase, p53Lyn, JTK8, p56Lyn, Tyrosine-protein kinase Lyn, LYN, V-yes-1 Yamaguchi sarcoma viral related oncogene homolog

Purification

Purified by antigen affinity column.

Accession

P07948

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Tyrosine-protein kinase Lyn is a ~58 kDa protein. Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4.

1. de Jesus, AA. et al. (2023) Nature communications 14, 1502. PMID: 36932076

2. Manié, SN. et al. (1997) The Journal of biological chemistry 272, 4230-6. PMID: 9020138

Note

For research use only.

Images

References

Datasheet

Anti-LYN Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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Anti-LYN Polyclonal Antibody (HY070014)

Overview

Images

References

Datasheet

SDS

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