Anti-CD98/SLC3A2 Polyclonal Antibody (HY415014)

Name: Anti-CD98/SLC3A2 Polyclonal Antibody
Brand: abinScience
SKU: HY415014
Price: 168 USD
Availability: InStock

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Overview
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Datasheet
SDS

Overview

Catalog No.

HY415014

Description

Anti-CD98/SLC3A2 Polyclonal Antibody (HY415014) is a rabbit polyclonal antibody detecting SLC3A2 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CD98/SLC3A2 (Leu213-Asp349).

Target

SLC3A2, 4F2hc, Lymphocyte activation antigen 4F2 large subunit, CD98, 4F2 cell-surface antigen heavy chain, Solute carrier family 3 member 2, MDU1, 4F2 heavy chain antigen

Purification

Purified by antigen affinity column.

Accession

P08195

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Amino acid transporter heavy chain SLC3A2 (CD98) is a ~57 kDa protein. Acts as a chaperone that facilitates biogenesis and trafficking of functional transporters heterodimers to the plasma membrane. Forms heterodimer with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11), a group of amino-acid antiporters. Heterodimers function as amino acids exchangers, the specificity of the substrate depending on the SLC7A subunit. Heterodimers SLC3A2/SLC7A6 or SLC3A2/SLC7A7 mediate the uptake of dibasic amino acids. Heterodimer SLC3A2/SLC7A11 functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane.

1. Rossier, G. et al. (1999) The Journal of biological chemistry 274, 34948-54. PMID: 10574970

2. Bröer, A. et al. (2000) The Biochemical journal 349 Pt 3, 787-95. PMID: 10903140

3. Yanagida, O. et al. (2001) Biochimica et biophysica acta 1514, 291-302. PMID: 11557028

4. Yan, R. et al. (2019) Nature 568, 127-130. PMID: 30867591

5. Yan, R. et al. (2020) Cell discovery 6, 82. PMID: 33298890

6. Yan, R. et al. (2021) Cell discovery 7, 16. PMID: 33758168

7. Parker, JL. et al. (2021) Nature communications 12, 7147. PMID: 34880232

8. Mastroberardino, L. et al. (1998) Nature 395, 288-91. PMID: 9751058

9. Torrents, D. et al. (1998) The Journal of biological chemistry 273, 32437-45. PMID: 9829974

10. Pfeiffer, R. et al. (1999) The EMBO journal 18, 49-57. PMID: 9878049

Note

For research use only.

Images

References

Datasheet

Anti-CD98/SLC3A2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-CD98/SLC3A2 Polyclonal Antibody (HY415014)

Overview

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References

Datasheet

SDS

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