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Anti-Integrin alpha L/CD11a Polyclonal Antibody (HB805014)

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Overview
Catalog No.HB805014
Description
Anti-CD11a/ITGAL Polyclonal Antibody (HB805014) is a rabbit polyclonal antibody detecting CD11A in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human CD11a/ITGAL (Asn809-His1066).
Target CD11A, Leukocyte function-associated molecule 1 alpha chain, Leukocyte adhesion glycoprotein LFA-1 alpha chain, LFA-1A, CD11 antigen-like family member A, CD11a, ITGAL, Integrin alpha-L
Purification Purified by antigen affinity column.
Accession P20701
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Integrin alpha-L (CD11a/ITGAL) is a ~128 kDa protein. Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R. Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity.

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3. de Fougerolles, AR. et al. (1991) The Journal of experimental medicine 174, 253-67. PMID: 1676048
4. Dustin, ML. et al. (1986) Journal of immunology (Baltimore, Md. : 1950) 137, 245-54. PMID: 3086451
5. Ostermann, G. et al. (2002) Nature immunology 3, 151-8. PMID: 11812992
6. Fraemohs, L. et al. (2004) Journal of immunology (Baltimore, Md. : 1950) 173, 6259-64. PMID: 15528364
7. Swaim, CD. et al. (2017) Molecular cell 68, 581-590.e5. PMID: 29100055
8. Barber, DF. et al. (2004) Journal of immunology (Baltimore, Md. : 1950) 173, 3653-9. PMID: 15356110
9. Lacouture, C. et al. (2024) Nature communications 15, 407. PMID: 38195629
10. Kristóf, E. et al. (2013) Apoptosis : an international journal on programmed cell death 18, 1235-51. PMID: 23775590
Note For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Integrin alpha L/CD11a Polyclonal Antibody

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