Anti-BMP6 Polyclonal Antibody (HB857014)

Name: Anti-BMP6 Polyclonal Antibody
Brand: abinScience
SKU: HB857014
Price: 96 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HB857014

Description

Anti-BMP6 Polyclonal Antibody (HB857014) is a rabbit polyclonal antibody detecting BMP6 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human BMP6 (Ser375-His513).

Target

VG-1-R, VG-1-related protein, Bone morphogenetic protein 6, VGR-1, BMP-6, VGR, BMP6

Purification

Purified by antigen affinity column.

Accession

P22004

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Bone morphogenetic protein 6 (BMP6) is a ~57 kDa protein. Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes including cartilage and bone formation. Also plays an important role in the regulation of HAMP/hepcidin expression and iron metabolism by acting as a ligand for hemojuvelin/HJV. Also acts to promote expression of HAMP, potentially via the interaction with its receptor BMPR1A/ALK3. Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2B. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target.

1. Seeherman, HJ. et al. (2019) Science translational medicine 11. PMID: 31019025

2. Daher, R. et al. (2016) Gastroenterology 150, 672-683.e4. PMID: 26582087

3. Arezes, J. et al. (2018) Blood 132, 1473-1477. PMID: 30097509

4. Wang, CY. et al. (2020) Blood 135, 453-456. PMID: 31800957

5. Saremba, S. et al. (2008) The FEBS journal 275, 172-83. PMID: 18070108

6. Pulkkinen, HH. et al. (2021) Angiogenesis 24, 129-144. PMID: 33021694

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-BMP6 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse heart lysate

References

Datasheet

Anti-BMP6 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-BMP6 Polyclonal Antibody (HB857014)

Overview

Images

References

Datasheet

SDS

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