Anti-SERPINB1 Polyclonal Antibody (HB906014)

Name: Anti-SERPINB1 Polyclonal Antibody
Brand: abinScience
SKU: HB906014
Price: 168 USD
Availability: InStock

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References
Datasheet
SDS

Overview

Catalog No.

HB906014

Description

Anti-SERPINB1 Polyclonal Antibody (HB906014) is a rabbit polyclonal antibody detecting SERPINB1 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human SERPINB1 (Leu13-Leu252).

Target

ELANH2, Peptidase inhibitor 2, Serpin B1, SERPINB1, MNEI, M/NEI, EI, LEI, PI2, Monocyte/neutrophil elastase inhibitor, PI-2, Leukocyte elastase inhibitor

Purification

Purified by antigen affinity column.

Accession

P30740

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Leukocyte elastase inhibitor (SERPINB1) is a ~42 kDa protein. Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis. Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Also acts as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity.

1. Choi, YJ. et al. (2019) Nature immunology 20, 276-287. PMID: 30692621

2. Cooley, J. et al. (2001) Biochemistry 40, 15762-70. PMID: 11747453

3. Wang, L. et al. (2013) Journal of immunology (Baltimore, Md. : 1950) 190, 1319-30. PMID: 23269243

4. El Ouaamari, A. et al. (2016) Cell metabolism 23, 194-205. PMID: 26701651

Note

For research use only.

Images

References

Datasheet

Anti-SERPINB1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-SERPINB1 Polyclonal Antibody (HB906014)

Overview

Images

References

Datasheet

SDS

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