Anti-AHR Polyclonal Antibody (HW686014)

Name: Anti-AHR Polyclonal Antibody
Brand: abinScience
SKU: HW686014
Price: 168 USD
Availability: InStock

Datasheet Share product Copy info

Price(USD):

Spec:

50ug
100ug

Number:

Get quote

Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HW686014

Description

Anti-AHR Polyclonal Antibody (HW686014) is a rabbit polyclonal antibody detecting AhR in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Mus caroli, and Mouse castaneus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human AHR (Val23-Gln273).

Target

bHLHe76, AhR, Ah receptor, AHR, Aryl hydrocarbon receptor, Class E basic helix-loop-helix protein 76, BHLHE76

Purification

Purified by antigen affinity column.

Accession

P35869

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Aryl hydrocarbon receptor (AHR) is a ~96 kDa protein. Ligand-activated transcription factor that enables cells to adapt to changing conditions by sensing compounds from the environment, diet, microbiome and cellular metabolism, and which plays important roles in development, immunity and cancer. Upon ligand binding, translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE). Regulates a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation. Xenobiotics can act as ligands: upon xenobiotic-binding, activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons.

1. MacPherson, L. et al. (2013) Nucleic acids research 41, 1604-21. PMID: 23275542

2. Gomez, A. et al. (2018) The Biochemical journal 475, 3827-3846. PMID: 30373764

3. Sadik, A. et al. (2020) Cell 182, 1252-1270.e34. PMID: 32818467

4. Ema, M. et al. (1994) The Journal of biological chemistry 269, 27337-43. PMID: 7961644

5. Puga, A. et al. (2002) Chemico-biological interactions 141, 117-30. PMID: 12213388

6. Borovok, N. et al. (2020) Frontiers in genetics 11, 582796. PMID: 33193710

7. Haidar, R. et al. (2021) Scientific reports 11, 18194. PMID: 34521881

9. Zhang, X. et al. (2020) Journal of agricultural and food chemistry 68, 10678-10684. PMID: 32866000

Note

For research use only.

Images

References

Datasheet

Anti-AHR Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-AHR Polyclonal Antibody (HW686014)

Overview

Images

References

Datasheet

SDS

Quick access

Contact Us