Anti-GLP1R Polyclonal Antibody (HW328014)

Name: Anti-GLP1R Polyclonal Antibody
Brand: abinScience
SKU: HW328014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HW328014

Description

Anti-GLP1R Polyclonal Antibody (HW328014) is a rabbit polyclonal antibody detecting GLP1R in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human GLP1R (Arg24-Tyr145).

Target

GLP-1 receptor, Glucagon-like peptide 1 receptor, GLP1R, GLP-1-R, GLP-1R

Purification

Purified by antigen affinity column.

Accession

P43220

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Glucagon-like peptide 1 receptor (GLP1R) is a ~53 kDa protein. G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1.

1. Underwood, CR. et al. (2010) The Journal of biological chemistry 285, 723-30. PMID: 19861722

2. Lau, J. et al. (2015) Journal of medicinal chemistry 58, 7370-80. PMID: 26308095

3. Hennen, S. et al. (2016) Scientific reports 6, 26236. PMID: 27196125

4. Song, G. et al. (2017) Nature 546, 312-315. PMID: 28514449

5. van Eyll, B. et al. (1994) FEBS letters 348, 7-13. PMID: 7517895

6. Graziano, MP. et al. (1993) Biochemical and biophysical research communications 196, 141-6. PMID: 8216285

7. Thorens, B. et al. (1993) Diabetes 42, 1678-82. PMID: 8405712

Note

For research use only.

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