

| Catalog No. | HW375014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-NR2C2 Polyclonal Antibody (HW375014) is a rabbit polyclonal antibody detecting NR2C2 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| Species reactivity | Human, Mouse, Rat | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Host species | Rabbit | ||||||||
| Isotype | IgG | ||||||||
| Clonality | Polyclonal | ||||||||
| Immunogen | E. coli - derived recombinant Human NR2C2 (Arg191-Pro503). | ||||||||
| Target | Orphan nuclear receptor TAK1, Orphan nuclear receptor TR4, TAK1, Nuclear receptor subfamily 2 group C member 2, TR4, NR2C2, Testicular receptor 4 | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Accession | P49116 | ||||||||
| Form | Liquid | ||||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Background | Nuclear receptor subfamily 2 group C member 2 (NR2C2) is a ~65 kDa protein. Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. | ||||||||
| Note | For research use only. |
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