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Anti-KPNA2 Polyclonal Antibody (HW788014)

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Overview
Catalog No.HW788014
Description
Anti-KPNA2 Polyclonal Antibody (HW788014) is a rabbit polyclonal antibody detecting KPNA2 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Species reactivityHuman, Mouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human KPNA2 (Ala157-Gln412).
Target SRP1-alpha, Karyopherin subunit alpha-2, RAG cohort protein 1, RCH1, Importin subunit alpha-1, KPNA2, SRP1
Purification Purified by antigen affinity column.
Accession P52292
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Importin subunit alpha-1 (KPNA2) is a ~57 kDa protein. Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

1. Zheng, W. et al. (2018) Traffic (Copenhagen, Denmark) 19, 19-28. PMID: 28991411
2. Cai, Z. et al. (2020) The Journal of experimental medicine 217. PMID: 32130408
3. Moroianu, J. et al. (1995) Proceedings of the National Academy of Sciences of the United States of America 92, 6532-6. PMID: 7604027
4. Weis, K. et al. (1995) Science (New York, N.Y.) 268, 1049-53. PMID: 7754385
5. Yang, TJ. et al. (2022) The Journal of cell biology 221. PMID: 35446349
Note For research use only.
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Datasheet
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Formula
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Anti-KPNA2 Polyclonal Antibody

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