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Anti-CRADD Polyclonal Antibody (HX957014)

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Overview
Catalog No.HX957014
Description
Anti-CRADD Polyclonal Antibody (HX957014) is a rabbit polyclonal antibody detecting CRADD in ELISA, IHC, WB. Suitable for Human, Mouse, and Pongo abelii.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human CRADD (Met1-Leu140).
Target RAIDD, CRADD, RIP-associated protein with a death domain, Caspase and RIP adapter with death domain, Death domain-containing protein CRADD
Purification Purified by antigen affinity column.
Accession P78560
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Death domain-containing protein CRADD is a ~22 kDa protein. Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis. Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway.

1. Tinel, A. et al. (2004) Science (New York, N.Y.) 304, 843-6. PMID: 15073321
2. Vakifahmetoglu, H. et al. (2006) Oncogene 25, 5683-92. PMID: 16652156
3. Tinel, A. et al. (2007) The EMBO journal 26, 197-208. PMID: 17159900
4. Park, HH. et al. (2007) Cell 128, 533-46. PMID: 17289572
5. Ahmad, M. et al. (1997) Cancer research 57, 615-9. PMID: 9044836
6. Duan, H. et al. (1997) Nature 385, 86-9. PMID: 8985253
Note For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Formula
C₁ × V₁ = C₂ × V₂
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C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-CRADD Polyclonal Antibody

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