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Anti-Human CD45/PTPRC Antibody (BC8) (HY195107)

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Anti-Human CD45/PTPRC Antibody (BC8)

Anti-Human CD45/PTPRC Antibody (BC8)

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Overview

Catalog No.	HY195107
Description	Anti-Human CD45/PTPRC Antibody (BC8) [BC8] (HY195107) is a mouse monoclonal antibody detecting PTPRC in FCM. Suitable for Human. Highlights ●Flow Cytometry — Validated for flow cytometry applications.
Species reactivity	Human
Applications	FCM
Host species	Mouse
Isotype	IgG1, kappa
Clone ID	BC8
Clonality	Monoclonal
Target	T200, Leukocyte common antigen, CD45, L-CA, Receptor-type tyrosine-protein phosphatase C, PTPRC
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P08575
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Receptor-type tyrosine-protein phosphatase C (CD45/PTPRC) is a ~147 kDa protein. Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity. 1. Dunlock, VE. et al. (2022) Cell reports 39, 111006. PMID: 35767951
Note	For research use only.

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Bioactivity

SEC-HPLC detection for Anti-Human CD45/PTPRC Antibody (BC8).

References

Datasheet

Anti-Human CD45/PTPRC Antibody (BC8).pdf

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Anti-Human CD45/PTPRC Antibody (BC8)