Anti-Mouse CD11a/ITGAL Antibody (FD441.8) (MB805107)

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Overview

Catalog No.	MB805107
Description	Anti-Mouse CD11a/ITGAL Antibody (FD441.8) [FD441.8] (MB805107) is a rat monoclonal antibody detecting CD11A in FCM, IF. Suitable for Mouse. Highlights ●Flow Cytometry — Validated for flow cytometry applications.
Species reactivity	Mouse
Applications	FCM, IF
Host species	Rat
Isotype	IgG2b
Clone ID	FD441.8
Clonality	Monoclonal
Target	CD11A, Leukocyte function-associated molecule 1 alpha chain, Leukocyte adhesion glycoprotein LFA-1 alpha chain, LFA-1A, CD11 antigen-like family member A, CD11a, ITGAL, Integrin alpha-L
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P24063
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Integrin alpha-L (CD11a/ITGAL) is a ~128 kDa protein. Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R. Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. 1. Kaufmann, Y. et al. (1991) Journal of immunology (Baltimore, Md. : 1950) 147, 369-74. PMID: 2051027 2. Swaim, CD. et al. (2017) Molecular cell 68, 581-590.e5. PMID: 29100055 3. Liu, Z. et al. (2006) Blood 107, 1063-9. PMID: 16234355 4. Jiang, E. et al. (2014) Arteriosclerosis, thrombosis, and vascular biology 34, 34-43. PMID: 24158516 5. Bose, TO. et al. (2014) Journal of immunology (Baltimore, Md. : 1950) 193, 2863-72. PMID: 25108025
Note	For research use only.

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SDS-PAGE for Anti-Mouse CD11a/ITGAL Antibody (FD441.8)

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Datasheet

Anti-Mouse CD11a/ITGAL Antibody (FD441.8).pdf

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Anti-Mouse CD11a/ITGAL Antibody (FD441.8) (MB805107)

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