Anti-Human BMP2 Recombinant Antibody (SAA0423) (HY576107)

Name: Anti-Human BMP2 Recombinant Antibody (SAA0423)
Brand: abinScience
SKU: HY576107
Price: 196 USD
Availability: InStock

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Overview

Catalog No.	HY576107
Species reactivity	Human
Applications	ELISA, FCM
Host species	Mouse
Isotype	IgG2a, kappa
Clone ID	SAA0423
Clonality	Monoclonal
Target	BMP-2, BMP2A, Bone morphogenetic protein 2A, Bone morphogenetic protein 2, BMP2, BMP-2A
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P12643
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.09% Sodium azide. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Bone morphogenetic protein 2 (BMP2) is a ~44 kDa protein. Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis. Induces cartilage and bone formation. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. 1. Lavery, K. et al. (2008) The Journal of biological chemistry 283, 20948-58. PMID: 18436533 2. Tanaka, K. et al. (2014) Calcified tissue international 94, 454-64. PMID: 24362451 3. Seeherman, HJ. et al. (2019) Science translational medicine 11. PMID: 31019025 4. Wozney, JM. et al. (1988) Science (New York, N.Y.) 242, 1528-34. PMID: 3201241 5. Keller, S. et al. (2004) Nature structural & molecular biology 11, 481-8. PMID: 15064755 6. Weber, D. et al. (2007) BMC structural biology 7, 6. PMID: 17295905 7. Liu, F. et al. (1995) Molecular and cellular biology 15, 3479-86. PMID: 7791754 8. Wang, CY. et al. (2020) Blood 135, 453-456. PMID: 31800957 9. Tsukahara, S. et al. (2006) The Biochemical journal 398, 595-603. PMID: 16771708
Note	For research use only.

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Flow Cytometry

Flow-cytometry using anti-human BMP2 antibody.HeLa cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human BMP2 antibody monoclonal antibody (Catalog # HY576107 ,Green Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a FITC conjugated goat anti-mouse antibody (Catalog # MF690414) and cells analysed on a NovoCyte Flow Cytometer.

References

Datasheet

Anti-Human BMP2 Recombinant Antibody (SAA0423).pdf

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Anti-Human BMP2 Recombinant Antibody (SAA0423) (HY576107)

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