Anti-Human CD106/VCAM1 Recombinant Antibody (H6) (HB032207)

Name: Anti-Human CD106/VCAM1 Recombinant Antibody (H6)
Brand: abinScience
SKU: HB032207
Price: 191 USD
Availability: InStock

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Overview

Catalog No.	HB032207
Species reactivity	Human
Applications	FCM
Host species	Rabbit
Isotype	IgG
Clone ID	H6
Clonality	Monoclonal
Target	Vascular cell adhesion protein 1, VCAM1, CD106, INCAM-100, V-CAM 1, VCAM-1
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P19320
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.09% Sodium azide. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Vascular cell adhesion protein 1 (CD106/VCAM1) is a ~81 kDa protein. Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation. Acts as a major regulator of leukocyte adhesion to the endothelium through interaction with different types of integrins. During inflammatory responses, binds ligands on the surface of activated endothelial cells to initiate the activation of calcium channels and the plasma membrane-associated small GTPase RAC1 leading to leukocyte transendothelial migration. Also serves as a quality-control checkpoint for entry into bone marrow by providing a 'don't-eat-me' stamping in the context of major histocompatibility complex (MHC) class-I presentation. 1. Li, Y. et al. (2020) Journal of molecular cell biology 12, 190-201. PMID: 31310649 2. Taooka, Y. et al. (1999) The Journal of cell biology 145, 413-20. PMID: 10209034 3. Marchese, ME. et al. (2012) Biochemistry 51, 8235-46. PMID: 22970700 4. Pinho, S. et al. (2022) Nature cell biology 24, 290-298. PMID: 35210567
Note	For research use only.

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SDS-PAGE for Anti-Human CD106/VCAM1 Antibody (H6)

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Datasheet

Anti-Human CD106/VCAM1 Recombinant Antibody (H6).pdf

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Anti-Human CD106/VCAM1 Recombinant Antibody (H6) (HB032207)

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