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Anti-Human CD38/ADPRC1 Antibody (HuMax-003) (HB691507)

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Anti-Human CD38/ADPRC1 Antibody (HuMax-003)

Anti-Human CD38/ADPRC1 Antibody (HuMax-003)

Anti-Human CD38/ADPRC1 Antibody (HuMax-003)

Anti-Human CD38/ADPRC1 Antibody (HuMax-003)

Anti-Human CD38/ADPRC1 Antibody (HuMax-003)

Anti-Human CD38/ADPRC1 Antibody (HuMax-003)

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Datasheet

Overview

Catalog No.	HB691507
Description	Anti-Human CD38/ADPRC1 Antibody (HuMax-003) [HuMax-003] (HB691507) is a mouse monoclonal antibody detecting CD38 in ELISA, FCM. Suitable for Human. Highlights ●Flow Cytometry — Validated for flow cytometry applications.
Species reactivity	Human
Applications	ELISA, FCM
Host species	Mouse
Isotype	IgG2a, kappa
Clone ID	HuMax-003
Clonality	Monoclonal
Target	Cyclic ADP-ribose hydrolase 1, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, cADPr hydrolase 1, 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase, T10, 2'-phospho-cyclic-ADP-ribose transferase, CD38, ADPRC 1, ADP-ribosyl cyclase 1, 2'-phospho-ADP-ribosyl cyclase
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P28907
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.09% Sodium azide. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38/ADPRC1) is a ~34 kDa protein. Multifunctional transmembrane glycoprotein able to exert enzymatic activities and also to mobilize calcium, to transduce signals, to adhere to hyaluronan and to other ligands. Synthesizes cyclic ADP-ribose (cADPR), a second messenger for glucose-induced insulin secretion. Synthesizes the Ca(2+) mobilizer nicotinate-adenine dinucleotide phosphate, NAADP(+), from 2'-phospho-cADPR and nicotinic acid, as well as from NADP(+) and nicotinic acid. At both pH 5.0 and pH 7.4 preferentially transforms 2'-phospho-cADPR into NAADP(+), while preferentially cleaving NADP(+) to cADPR and ADPRP rather than into NADDP(+). Has cADPR hydrolase activity. 1. Tohgo, A. et al. (1994) The Journal of biological chemistry 269, 28555-7. PMID: 7961800 2. Takasawa, S. et al. (1993) The Journal of biological chemistry 268, 26052-4. PMID: 8253715 3. Moreschi, I. et al. (2006) Biochemical and biophysical research communications 345, 573-80. PMID: 16690024 4. Deaglio, S. et al. (1998) Journal of immunology (Baltimore, Md. : 1950) 160, 395-402. PMID: 9551996 5. Frasca, L. et al. (2006) Blood 107, 2392-9. PMID: 16293598 6. Deaglio, S. et al. (2001) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 15, 580-2. PMID: 11259373
Note	For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human CD38/ADPRC1 Antibody (HuMax-003)
Bioactivity

Detects recombinant human CD38 (Catalog No: HB691021) in indirect ELISA
Western blot

Western blot analysis was performed using anti-CD38 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human CD38 (Catalog No: HB691021)
Lane 2: negative control
Lane 3: negative control

References

Datasheet

Anti-Human CD38/ADPRC1 Antibody (HuMax-003).pdf

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Anti-Human CD38/ADPRC1 Antibody (HuMax-003)