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Anti-Human CD305/LAIR1 Antibody (LA-94), APC (HV765137)

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Overview

Catalog No.	HV765137
Description	Anti-Human CD305/LAIR1 Antibody (LA-94), APC [LA-94] (HV765137) is a mouse monoclonal antibody detecting LAIR1 in FCM. Suitable for Human. Highlights ●Flow Cytometry — Validated for flow cytometry applications. ●Fluorescent Label — Direct conjugate for streamlined workflows.
Species reactivity	Human
Applications	FCM
Host species	Mouse
Isotype	IgG1, kappa
Clone ID	LA-94
Conjugation	APC
Clonality	Monoclonal
Target	Leukocyte-associated immunoglobulin-like receptor 1, LAIR-1, hLAIR1, LAIR1, CD305
Endotoxin level	Please contact with the lab for this information.
Accession	Q6GTX8
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	Leukocyte-associated immunoglobulin-like receptor 1 (CD305/LAIR1) is a ~31 kDa protein. Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta.
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Datasheet

Anti-Human CD305/LAIR1 Antibody (LA-94), APC.pdf

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Anti-Human CD305/LAIR1 Antibody (LA-94), APC