Anti-Rabies virus G/Glycoprotein Antibody (17C7) (VK584013)

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1mg

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Overview
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Datasheet

Overview

Catalog No.

VK584013

Description

Anti-Rabies virus G/Glycoprotein Antibody (17C7) [17C7] (VK584013) is a human monoclonal antibody detecting Glycoprotein in ELISA, Neutralization. Suitable for Rabies virus (RABV).

Species reactivity

Rabies virus (RABV)

Applications

ELISA, Neutralization

Host species

Human

Isotype

IgG1, kappa

Clone ID

17C7

Clonality

Monoclonal

Target

G, Glycoprotein

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P03524

RRID

Anti-Rabies virus G/Glycoprotein Antibody (17C7) (abinScience Cat# VK584013, RRID:AB_3725279)

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Glycoprotein is a ~58 kDa protein. Attaches the virus to host cellular receptor, inducing endocytosis of the virion by using different host proteins including TFRC, GRM2 and ITGB1. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells.

Note

For research use only.

Images

Bioactivity

SEC-HPLC detection for Anti-Rabies virus G/Glycoprotein Antibody (17C7).
SDS-PAGE

SDS-PAGE for Anti-Rabies virus G/Glycoprotein Antibody (17C7).
Bioactivity

Detects Recombinant RABV G/Glycoprotein, C-His (Cat No.: VK584011) in indirect ELISA.