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InVivoMAb Anti-HHV-5/HCMV HHRF3/US28 Antibody (Iv0102) (VK595010)

InVivoMAb Anti-HHV-5/HCMV HHRF3/US28 Antibody (Iv0102)
InVivoMAb Anti-HHV-5/HCMV HHRF3/US28 Antibody (Iv0102)
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  • 100ug
  • 1mg
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Overview
Catalog No.VK595010
Description
InVivoMAb Anti-HHV-5/HCMV HHRF3/US28 (Iv0102) [Iv0102] (VK595010) is a alpaca monoclonal antibody detecting G-protein coupled receptor homolog US28 in ELISA, Neutralization.
Species reactivityHuman adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5)
ApplicationsELISA, Neutralization
Host speciesAlpaca
ClonalityMonoclonal
IsotypeVHH-His
Clone IDIv0102
Target G-protein coupled receptor homolog US28, HHRF3, US28
Endotoxin level <0.01 EU/ug
Purity >95% as determined by SDS-PAGE.
Associated products pH 7.4 Dilution Buffer
Purification Purified by Nickel column.
Accession P69332, P69333
Form Liquid
Storage buffer 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

G-protein coupled receptor homolog US28 (HHRF3) is a ~41 kDa protein. Viral chemokine receptor that plays a critical role in viral pathogenesis, mediating several processes such as cellular migration, differentiation, transformation, and viral latency and reactivation. Binds to a great number of different CC-chemokines including CCL5/RANTES, CCL2/MCP-1, CCL3/MIP-1-alpha as well as CX3CL1/Fractalkine. Transduces signals resulting in the activation of MAP kinase signaling pathways and augmentation of intracellular calcium ion levels, leading to alterations in chemotactic behavior of vascular smooth muscle cells and macrophages. The US28 receptor also exhibits high levels of agonist-independent signaling activity and agonist-independent endocytosis. Interacts with the host Gi complex without activating it, thereby probably interfering with the chemokine-Gi signaling.

1. Miles, TF. et al. (2018) eLife 7. PMID: 29882741
Note For research use only. Not suitable for clinical or therapeutic use.
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  • InVivoMAb Anti-HHV-5/HCMV HHRF3/US28 Antibody (Iv0102)

    SDS-PAGE

    SDS-PAGE for InVivoMAb Anti-HHV-5/HCMV HHRF3/US28 (Iv0102)

References
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Formula
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