InVivoMAb Anti-SEBOV/ZEBOV GP/Envelope glycoprotein Antibody (Iv0198) (VK623050)

Name: InVivoMAb Anti-SEBOV/ZEBOV GP/Envelope glycoprotein Antibody (Iv0198)
Brand: abinScience
SKU: VK623050
Price: 370 USD
Availability: InStock

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Catalog No.	VK623050
Description	InVivoMAb Anti-SEBOV/ZEBOV GP/Envelope glycoprotein Antibody (Iv0198) [Iv0198] (VK623050) is a human monoclonal antibody detecting Envelope glycoprotein in ELISA, FCM, Neutralization. Suitable for Ebola virus and Zaire ebolavirus. Highlights ●Multi-Application — Validated across multiple applications. ●Flow Cytometry — Validated for flow cytometry applications.
Species reactivity	Sudan ebolavirus (SEBOV) (Sudan Ebola virus), Zaire ebolavirus (ZEBOV) (Zaire Ebola virus)
Applications	ELISA, FCM, Neutralization
Host species	Human
Isotype	IgG
Clone ID	Iv0198
Clonality	Monoclonal
Target	Envelope glycoprotein, GP1, 2, GP, Shed GP, GP1, 2-delta, GP1, GP2, GP
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Associated products	pH 7.4 Dilution Buffer
Purification	Protein A/G purified from cell culture supernatant.
Accession	P87666, O11457, Q05320, Q9YMG2, P0C773, Q7T9D9
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Envelope glycoprotein (GP) is a ~74 kDa protein. Trimeric GP1,2 complexes form the virion surface spikes and mediate the viral entry processes, with GP1 acting as the receptor-binding subunit and GP2 as the membrane fusion subunit. At later times of infection, down-regulates the expression of various host cell surface molecules that are essential for immune surveillance and cell adhesion. Down-modulates several integrins including ITGA1, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGAV and ITGB1. This decrease in cell adhesion molecules may lead to cell detachment, contributing to the disruption of blood vessel integrity and hemorrhages developed during infection (cytotoxicity). Interacts with host TLR4 and thereby stimulates the differentiation and activation of monocytes leading to bystander death of T-lymphocytes.
Note	For research use only. Not suitable for clinical or therapeutic use.

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InVivoMAb Anti-SEBOV/ZEBOV GP/Envelope glycoprotein Antibody (Iv0198).pdf

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InVivoMAb Anti-SEBOV/ZEBOV GP/Envelope glycoprotein Antibody (Iv0198) (VK623050)

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