Anti-Human ErbB2/Her2 & ErbB3/Her3 Bispecific Reference Antibody (Zenocutuzumab, RUO) (HY286096)

Name: Anti-Human ErbB2/Her2 & ErbB3/Her3 Bispecific Reference Antibody (Zenocutuzumab, RUO)
Brand: abinScience
SKU: HY286096
Price: 176 USD
Availability: InStock

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SDS

Overview

Catalog No.	HY286096
Description	Zenocutuzumab (HY286096) is a research-grade recombinant antibody targeting CD340. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG1-kappa
Expression system	Mammalian cells
Clonality	Monoclonal
Target	p185erbB2, HER2, NGL, Tyrosine kinase-type cell surface receptor HER2, NEU, MLN 19, Proto-oncogene Neu, MLN19, ERBB2, Proto-oncogene c-ErbB-2, CD340, Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein, ERBB3, HER3, Proto-oncogene-like protein c-ErbB-3, Tyrosine kinase-type cell surface receptor HER3, Receptor tyrosine-protein kinase erbB-3
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P04626 & P21860
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	Bispecific, MCLA-128, PB4188, R040517, 1969309-56-5
Background	Zenocutuzumab (MCLA-128) is a bispecific humanized IgG1 antibody containing two different Fab arms, targeting extracellular domains of HER2 and HER3.
Note	For research use only. Not suitable for clinical or therapeutic use.

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Bioactivity

Detects CD340/ERBB2/HER2/NEU in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Research Grade Zenocutuzumab
Flow CytoMetry

Flow-cytometry using anti-human ERBB3 antibody. Untransfected cells (blue Histogram) and Transfected cells (Yellow Histogram) were stained with an anti-human ERBB3 monoclonal antibody (Catalog: HY286096) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a Goat Anti-Human IgG H&L Polyclonal Antibody, FITC (abinScience: HF690414) and cells analysed on a NovoCyte Flow Cytometer.
Western blot

Western blot analysis was performed using anti-CD340/ERBB2 monoclonal antibody at 1μg/ml on various samples.
Lane 1: recombinant human CD340/ERBB2 (Catalog No: HY286011)

References

Datasheet

Anti-Human ErbB2/Her2 & ErbB3/Her3 Bispecific Reference Antibody (Zenocutuzumab, RUO).pdf

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Recombinant Proteins

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Anti-Human ErbB2/Her2 & ErbB3/Her3 Bispecific Reference Antibody (Zenocutuzumab, RUO) (HY286096)

Overview

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References

Datasheet

SDS

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