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Research Grade Sabatolimab (HV029026)

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Research Grade Sabatolimab

Research Grade Sabatolimab

Research Grade Sabatolimab

Research Grade Sabatolimab

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100ug
1mg

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References
Datasheet

Overview

Catalog No.	HV029026
Description	Sabatolimab (HV029026) is a research-grade recombinant antibody targeting CD366. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Humanized
Isotype	IgG4-kappa
Expression system	Mammalian Cells
Clonality	Monoclonal
Target	T-cell immunoglobulin mucin receptor 3, HAVcr-2, TIMD-3, T-cell membrane protein 3, HAVCR2, Hepatitis A virus cellular receptor 2, CD366, TIMD3, TIM-3, TIM3, T-cell immunoglobulin and mucin domain-containing protein 3
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q8TDQ0
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Alternate Names	MBG-453, 2252262-24-9
Background	Hepatitis A virus cellular receptor 2 (CD366/TIM-3) is a ~33 kDa protein. Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. 1. Gorman, JV. et al. (2014) Immunologic research 59, 56-65. PMID: 24825777 2. Monney, L. et al. (2002) Nature 415, 536-41. PMID: 11823861 3. Sánchez-Fueyo, A. et al. (2003) Nature immunology 4, 1093-101. PMID: 14556005 4. Clayton, KL. et al. (2014) Journal of immunology (Baltimore, Md. : 1950) 192, 782-91. PMID: 24337741 5. Tomkowicz, B. et al. (2015) PloS one 10, e0140694. PMID: 26492563 6. Gautron, AS. et al. (2014) European journal of immunology 44, 2703-2711. PMID: 24838857 7. Zhu, C. et al. (2005) Nature immunology 6, 1245-52. PMID: 16286920 8. Leitner, J. et al. (2013) PLoS pathogens 9, e1003253. PMID: 23555261 9. Gleason, MK. et al. (2012) Blood 119, 3064-72. PMID: 22323453
Note	For research use only. Not suitable for clinical or therapeutic use.

Images

Bioactivity

SEC-HPLC detection for Research Grade Sabatolimab.
SDS-PAGE

SDS-PAGE for Research Grade Sabatolimab

References

Datasheet

Research Grade Sabatolimab.pdf

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Research Grade Sabatolimab