| Catalog No. | HV514016 |
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| Species reactivity | Human |
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| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Host species | Humanized |
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| Isotype | IgG1-kappa |
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| Expression system |
Mammalian Cells |
| Clonality |
Monoclonal |
| Target |
RSPO3, hPWTSR, hRspo3, PWTSR, R-spondin-3, Thrombospondin type-1 domain-containing protein 2, Protein with TSP type-1 repeat, Roof plate-specific spondin-3, THSD2 |
| Endotoxin level |
Please contact the lab for this information. |
| Purity |
>95% purity as determined by SDS-PAGE. |
| Purification |
Protein A/G purified from cell culture supernatant. |
| Accession |
Q9BXY4 |
| Form |
Liquid |
| Storage buffer |
0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
|
| Stability and Storage |
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Alternate Names | OMP-131R10, 1684393-04-1 |
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| Background | Rosmantuzumab (OMP-131R10) is an anti-R-spondin 3 (RSPO3) humanized monoclonal antibody. Rosmantuzumab can be used for the research of advanced telapsed and refractory solid tumors.
• Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis., PMID:31348891
• Hepatic stellate cells control liver zonation, size and functions via R-spondin 3., PMID:40074890
• Organoid cultures of early-onset colorectal cancers reveal distinct and rare genetic profiles., PMID:32217638
• Endothelial RSPO3 mediates pulmonary endothelial regeneration by LGR4-dependent activation of β-catenin and ILK signaling pathways after inflammatory vascular injury., PMID:38677673
• The role of R-spondin proteins in cancer biology., PMID:34663878
• Estradiol and RSPO3 regulate vertebral trabecular bone mass independent of each other., PMID:35068191
• RSPO3 regulates the radioresistance of Non-Small cell lung cancer cells via NLRP3 Inflammasome-Mediated pyroptosis., PMID:39245068
• R-spondin3 promotes the tumor growth of choriocarcinoma JEG-3 cells., PMID:31851527
• R-spondin 3 regulates dorsoventral and anteroposterior patterning by antagonizing Wnt/β-catenin signaling in zebrafish embryos., PMID:24918770
• RSPO3 promotes the aggressiveness of bladder cancer via Wnt/β-catenin and Hedgehog signaling pathways., PMID:30329043
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| Note |
For research use only. Not suitable for clinical or therapeutic use. |
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