| Catalog No. | HB801016 |
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| Species reactivity | Human |
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| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Host species | Chimeric |
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| Isotype | IgG1-kappa |
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| Expression system | Mammalian Cells |
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| Clonality | Monoclonal |
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| Target | PRLR, PRL-R, Prolactin receptor |
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| Endotoxin level | Please contact the lab for this information. |
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| Purity | >95% purity as determined by SDS-PAGE. |
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| Purification | Protein A/G purified from cell culture supernatant. |
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| Accession | P16471 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS, pH 7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
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| Alternate Names | PR-1594804, h16f, ABBV-176, DC-1630993, h16f, Rolinsatamabtalirine, 2095467-30-2 |
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| Background | Rolinsatamab is a IgG1κ type chimeric antibody targeting to PRLR (prolactin receptor). Rolinsatamab can be conjugated with pyrrolobenzodiazepine (PDB) dimer SGD-1882 (HY-101127) via a cleavable maleimidocaproyl type linker, to form an antibody-drug conjugate, Rolinsatamab talirine. One Rolinsatamab talirine has an average of 2 site-specific drug attachment engineered cysteines (S239C). The linker equips the valine-alanine dipeptide, as cathepsine B cleavage site. on an average of 2 site-specific drug attachment engineered cysteines (S239C).
• Prolactin and autoimmunity., PMID:12848992
• PRL-R Variants Are Not Only Associated With Prolactinomas But Also With Dopamine Agonist Resistance., PMID:36638053
• High plasma prolactin is associated with PRL-R and predicts poor prognosis in Chinese postmenopausal women with breast cancer., PMID:40377604
• Expression of the prolactin receptor (tiPRL-R) gene in tilapia Oreochromis niloticus: tissue distribution and cellular localization in osmoregulatory organs., PMID:10750022
• Biological and clinical aspects of prolactin receptors (PRL-R) in human breast cancer., PMID:2285609
• New insights in prolactin: pathological implications., PMID:25781857
• Detection of prolactin receptor (PRL-R) mRNA in the rat hypothalamus and pituitary gland., PMID:1537321
• Prolactin - a pleiotropic factor in health and disease., PMID:30899100
• Prolactin and its receptor in human endometrium., PMID:10406072
• Increase in prolactin receptor (PRL-R) mRNA level in the mammary gland after hormonal induction of lactation in virgin ewes., PMID:10701763
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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