| Catalog No. | HP656016 |
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| Species reactivity | Human |
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| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Host species | Human |
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| Isotype | IgG2-kappa |
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| Expression system | Mammalian Cells |
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| Clonality | Monoclonal |
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| Target | SLITRK6, SLIT and NTRK-like protein 6 |
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| Endotoxin level | Please contact the lab for this information. |
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| Purity | >95% purity as determined by SDS-PAGE. |
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| Purification | Protein A/G purified from cell culture supernatant. |
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| Accession | Q9H5Y7 |
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| Form | Liquid |
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| Storage buffer | 30 mM Histidine, pH5.8, 10% sucrose, 0.02% Tween80 |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
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| Alternate Names | AGS15C, Ha15-10ac12, Ha15-10ac12.1, 1824663-82-2 |
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| Background | Sirtratumab is a human Igγ2 monoclonal antibody against SLIT and NTRK-like family 6 (Slitrk6). Sirtratumab can be used in research of cancer.
• SLITRK6 promotes the progression of lung adenocarcinoma by regulating PI3K/AKT/mTOR signaling and Warburg effect., PMID:37219677
• SLITRK6 mutations cause myopia and deafness in humans and mice., PMID:23543054
• Differential expression of SLITRK6 gene as a potential therapeutic target for urothelial carcinoma in particular upper tract cancer., PMID:37353040
• The role of SLITRK6 in the pathogenesis of Tourette syndrome: From the conclusion of a family-based study in the Chinese Han population., PMID:32037697
• A novel mutation in SLITRK6 causes deafness and myopia in a Moroccan family., PMID:29551497
• A homozygous SLITRK6 nonsense mutation is associated with progressive auditory neuropathy in humans., PMID:23946138
• Transcriptomic Profiling Discloses Molecular and Cellular Events Related to Neuronal Differentiation in SH-SY5Y Neuroblastoma Cells., PMID:27422411
• Human cytomegalovirus downregulates SLITRK6 expression through IE2., PMID:27530937
• Born This Way: Using Intrinsic Disorder to Map the Connections between SLITRKs, TSHR, and Male Sexual Orientation., PMID:30156382
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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