| Catalog No. | JN822016 |
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| Species reactivity | Escherichia coli |
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| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Host species | Chimeric |
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| Isotype | IgG1-kappa |
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| Expression system | Mammalian Cells |
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| Clonality | Monoclonal |
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| Target | shiga toxin type 2stx2A |
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| Endotoxin level | Please contact the lab for this information. |
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| Purity | >95% purity as determined by SDS-PAGE. |
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| Purification | Protein A/G purified from cell culture supernatant. |
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| Accession | P09385 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS, pH 7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
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| Alternate Names | Shigamabs(drugnameforthecombinationofpritoxaximabandsetoxaximab), caStx2, 1351470-17-1 |
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| Background | Setoxaximab is an IgG1-κ humanized chimeric antibody targeting shiga toxin type 1.
• Shiga Toxin (Stx) Classification, Structure, and Function., PMID:25530917
• Shiga-toxin-converting bacteriophages., PMID:11686382
• Escherichia albertii Pathogenesis., PMID:32588811
• Shiga Toxin-Producing Escherichia coli Infections during Pregnancy., PMID:30360505
• Switching Shiga Toxin (Stx) Type from Stx2d to Stx2a but Not Stx2c Alters Virulence of Stx-Producing Escherichia coli (STEC) Strain B2F1 in Streptomycin (Str)-Treated Mice., PMID:33467588
• Targeting bacterial toxins., PMID:22441768
• Shiga toxin-induced haemolytic uraemic syndrome and the role of antibiotics: a global overview., PMID:31150744
• L-Arabinose inhibits Shiga toxin type 2-converting bacteriophage induction in Escherichia coli O157:H7., PMID:37332116
• Shiga toxin 2a and Enteroaggregative Escherichia coli--a deadly combination., PMID:26039753
• Shiga Toxin (Stx) Type 1a and Stx2a Translocate through a Three-Layer Intestinal Model., PMID:36977098
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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