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Anti-Influenza B virus HA/Hemagglutinin Reference Antibody (Lesofavumab, RUO) (VK515056)

Anti-Influenza B virus HA/Hemagglutinin Reference Antibody (Lesofavumab, RUO)
Anti-Influenza B virus HA/Hemagglutinin Reference Antibody (Lesofavumab, RUO)
Anti-Influenza B virus HA/Hemagglutinin Reference Antibody (Lesofavumab, RUO)
Anti-Influenza B virus HA/Hemagglutinin Reference Antibody (Lesofavumab, RUO)
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  • Overview

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  • References

  • Datasheet

  • SDS

Overview
Catalog No.VK515056
Description
Lesofavumab (VK515056) is a research-grade recombinant antibody targeting HA/Hemagglutinin. Produced in mammalian cells with native-like glycosylation.
Highlights
  • Research Grade — For PK/PD studies, assay development, and ADA research.
  • Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivityInfluenza B virus
ApplicationsELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host speciesHuman
IsotypeIgG1, kappa
Expression system Mammalian cells
Clonality Monoclonal
Target HA/Hemagglutinin
Endotoxin level < 10 EU/mg
Purity >95% purity as determined by SDS-PAGE.
Purification Protein A/G purified from cell culture supernatant.
Accession P03461
Form Liquid
Storage buffer 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate NamesRG6024, RG6024, MHAB5553A, RG70026, RO7045557, 1807960-57-1
Background

Hemagglutinin (HA) is a ~62 kDa protein. Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induce an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide.

Note For research use only. Not suitable for clinical or therapeutic use.
Images
  • Anti-Influenza B virus HA/Hemagglutinin Reference Antibody (Lesofavumab, RUO)

    Bioactivity

    SEC-HPLC detection for Research Grade Lesofavumab.

  • Anti-Influenza B virus HA/Hemagglutinin Reference Antibody (Lesofavumab, RUO)

    SDS-PAGE

    SDS-PAGE for Research Grade Lesofavumab

References
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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