| Catalog No. | HF813016 |
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| Species reactivity | Human |
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| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Host species | Human |
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| Isotype | IgG1-lambda |
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| Expression system | Mammalian Cells |
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| Clonality | Monoclonal |
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| Target | Interferon gamma, IFN-gamma, Immune interferon, IFNG |
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| Endotoxin level | Please contact the lab for this information. |
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| Purity | >95% purity as determined by SDS-PAGE. |
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| Purification | Protein A/G purified from cell culture supernatant. |
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| Accession | P01579 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS, pH 7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
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| Alternate Names | NI-0501, emapalumab-lzsg, 1709815-23-5 |
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| Background | Emapalumab (NI-0501) is a human monoclonal IgG1 antibody that noncompetitively inhibits IFN-γ. Emapalumab binds with high affinity (Kd= 1.4 pM) to both free IFN-γ as well as IFN-γ bound to its receptor. Emapalumab can be used in research of hemophagocytic lymphohistiocytosis (HLH).
• Interferon-γ induces tumor resistance to anti-PD-1 immunotherapy by promoting YAP phase separation., PMID:33606996
• Dysregulation in IFN-γ signaling and response: the barricade to tumor immunotherapy., PMID:37275859
• IFN-γ drives inflammatory bowel disease pathogenesis through VE-cadherin-directed vascular barrier disruption., PMID:31566580
• IFN-γ Contributes to the Immune Mechanisms of Hypertension., PMID:36591357
• Liver type 1 innate lymphoid cells develop locally via an interferon-γ-dependent loop., PMID:33766856
• Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche., PMID:29950724
• IRAK1-regulated IFN-γ signaling induces MDSC to facilitate immune evasion in FGFR1-driven hematological malignancies., PMID:34906138
• Interferon-gamma release assay performance in northeastern Brazil: influence of the IFNG+874 A>T polymorphism., PMID:29787713
• Restraint of IFN-γ expression through a distal silencer CNS-28 for tissue homeostasis., PMID:37040761
• MUC1-C integrates activation of the IFN-γ pathway with suppression of the tumor immune microenvironment in triple-negative breast cancer., PMID:33495298
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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