| Catalog No. | HV066016 |
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| Species reactivity | Human |
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| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Host species | Human |
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| Isotype | IgG1-Kappa |
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| Expression system | Mammalian Cells |
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| Clonality | Monoclonal |
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| Target | Neurotensin receptor 3, Gp95, Glycoprotein 95, Sortilin, 100 kDa NT receptor, NTR3, SORT1, NT3 |
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| Endotoxin level | Please contact the lab for this information. |
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| Purity | >95% purity as determined by SDS-PAGE. |
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| Purification | Protein A/G purified from cell culture supernatant. |
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| Accession | Q99523 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS, pH 7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
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| Alternate Names | AL001, 2376132-27-1 |
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| Background | Latozinemab (AL001) is a recombinant human anti-Sortilin monoclonal antibody. Latozinemab effectively binds Sortilin with a high affinity and blocks the interaction between progranulin protein (PGRN) and Sortilin receptor. Latozinemab has the potential for progranulin gene (GRN) mutations causative of Frontotemporal dementia (FTD) (FTD-GRN) research.
• The 100-kDa neurotensin receptor is gp95/sortilin, a non-G-protein-coupled receptor., PMID:9756851
• Sortilin is dispensable for secondary injury processes following traumatic brain injury in mice., PMID:39170542
• Neurotrophins and their involvement in digestive cancers., PMID:30741921
• Sortilin Modulates Schwann Cell Signaling and Remak Bundle Regeneration Following Nerve Injury., PMID:35634462
• Peptides other than the neurotrophins that can be cleaved from proneurotrophins: a neglected story., PMID:17917853
• The Neurotrophin Receptor TrkC as a Novel Molecular Target of the Antineuroblastoma Action of Valproic Acid., PMID:34360553
• Proneurotrophin-3 may induce Sortilin-dependent death in inner ear neurons., PMID:21261755
• Neurotrophins and their receptors in early development of the mammalian nervous system., PMID:21196952
• Proneurotrophin-3 is a neuronal apoptotic ligand: evidence for retrograde-directed cell killing., PMID:19940174
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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