| Catalog No. | HC517016 |
|---|
| Species reactivity | Human |
|---|
| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
|---|
| Host species | Human |
|---|
| Isotype | IgG1-kappa |
|---|
| Expression system |
Mammalian Cells |
| Clonality |
Monoclonal |
| Target |
IFN-gamma-inducing factor, IL1F4, Interleukin-1 gamma, IL-18, IL-1 gamma, Interleukin-18, Interferon gamma-inducing factor, IGIF, IL18, Iboctadekin |
| Endotoxin level |
Please contact the lab for this information. |
| Purity |
>95% purity as determined by SDS-PAGE. |
| Purification |
Protein A/G purified from cell culture supernatant. |
| Accession |
Q14116 |
| Form |
Liquid |
| Storage buffer |
0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
|
| Stability and Storage |
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Background | Camoteskimab (AVTX-007) is an anti-IL-18 monoclonal antibody with fully humanized, high-affinity. Camoteskimab is promising for research of cardiovascular diseases and autoinflammatory diseases, including adult-onset Still’s disease (AOSD) and multiple myeloma.
• Mechanism and Regulation of NLRP3 Inflammasome Activation., PMID:27669650
• Inflammasomes in neuroinflammatory and neurodegenerative diseases., PMID:31015277
• IL-27 enhances IL-15/IL-18-mediated activation of human natural killer cells., PMID:31277710
• Augmentation of Antitumor Immunity by Human and Mouse CAR T Cells Secreting IL-18., PMID:28954221
• NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis., PMID:29880500
• Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases., PMID:31874111
• ACSL6-activated IL-18R1-NF-κB promotes IL-18-mediated tumor immune evasion and tumor progression., PMID:39292786
• Pretreatment with IL-15 and IL-18 rescues natural killer cells from granzyme B-mediated apoptosis after cryopreservation., PMID:38729924
• Interleukin-18 and COVID-19., PMID:34911594
• Short IL-18 generated by caspase-3 cleavage mobilizes NK cells to suppress tumor growth., PMID:39891018
|
|---|
| Note |
For research use only. Not suitable for clinical or therapeutic use. |
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