Anti-SARS-CoV-2 RBD Broad-Neutralizing Reference Antibody (002-S21F2, RUO) (VK565326)

Name: Anti-SARS-CoV-2 RBD Broad-Neutralizing Reference Antibody (002-S21F2, RUO)
Brand: abinScience
SKU: VK565326
Price: 370 USD
Availability: InStock

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References
Datasheet
SDS

Overview

Catalog No.	VK565326
Description	Anti-SARS-CoV-2 Spike Protein/RBD Broad-Neutralizing Antibody (002-S21F2) (VK565326) is a research-grade recombinant antibody targeting Spike glycoprotein. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Applications	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
Host species	Human
Clonality	Monoclonal
Isotype	IgG1
Clone ID	002-S21F2
Target	Spike glycoprotein, Spike, S glycoprotein, RBD
Endotoxin level	< 10 EU/mg
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P0DTC2
Form	Liquid
Storage buffer	0.01M PBS pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Spike glycoprotein (RBD) is a ~141 kDa protein. Attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. The major receptor is host ACE2. When S2/S2' has been cleaved, binding to the receptor triggers direct fusion at the cell membrane. When S2/S2' has not been cleaved, binding to the receptor results in internalization of the virus by endocytosis using host TFRC and GRM2 and leading to fusion of the virion membrane with the host endosomal membrane. Alternatively, may use NRP1/NRP2 and integrin as entry receptors. 1. Hoffmann, M. et al. (2020) Cell 181, 271-280.e8. PMID: 32142651 2. Walls, AC. et al. (2020) Cell 181, 281-292.e6. PMID: 32155444 3. Cao, W. et al. (2021) Biophysical journal 120, 1011-1019. PMID: 33607086 4. Takeda, M. (2022) Microbiology and immunology 66, 15-23. PMID: 34561887 5. Wrapp, D. et al. (2020) Science (New York, N.Y.) 367, 1260-1263. PMID: 32075877 6. Ou, X. et al. (2020) Nature communications 11, 1620. PMID: 32221306 7. Wang, J. et al. (2021) Cell discovery 7, 119. PMID: 34903715 8. Wang, X. et al. (2023) Journal of virology 97, e0161122. PMID: 36779763 9. Daly, JL. et al. (2020) Science (New York, N.Y.) 370, 861-865. PMID: 33082294 10. Cantuti-Castelvetri, L. et al. (2020) Science (New York, N.Y.) 370, 856-860. PMID: 33082293
Note	For research use only. Not suitable for clinical or therapeutic use.

Images

Bioactivity

Detects Recombinant SARS-CoV-2 RBD (Omicron/BA.2) Protein, C-His (Cat No.: VK565241) in indirect ELISA.
Bioactivity

Detects Recombinant SARS-CoV-2 RBD (Omicron XBB.1.5) Protein, C-His (Cat No.: VK565311) in indirect ELISA.
SDS-PAGE

SDS-PAGE for Research Grade Anti-SARS-CoV-2 Spike Protein/RBD Broad-Neutralizing Antibody (002-S21F2).