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Research Grade Anti-Human TREM2 Antibody (al002) (HV166016)

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Research Grade Anti-Human TREM2 Antibody (al002)

Research Grade Anti-Human TREM2 Antibody (al002)

Research Grade Anti-Human TREM2 Antibody (al002)

Research Grade Anti-Human TREM2 Antibody (al002)

Research Grade Anti-Human TREM2 Antibody (al002)

Research Grade Anti-Human TREM2 Antibody (al002)

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Spec:

100ug
1mg

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Overview
Images
References
Datasheet

Overview

Catalog No.	HV166016
Description	Anti-Human TREM2 Antibody (al002) (HV166016) is a research-grade recombinant antibody targeting Triggering receptor expressed on myeloid cells 2. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human, Mouse
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Humanized
Isotype	IgG1-kappa
Clone ID	al002
Expression system	Mammalian Cells
Clonality	Monoclonal
Target	Triggering receptor expressed on myeloid cells 2, Triggering receptor expressed on monocytes 2, TREM-2, TREM2
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q9NZC2
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Background	Triggering receptor expressed on myeloid cells 2 (TREM2) is a ~25 kDa protein. Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding. Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia. Binding to amyloid-beta 42 mediates microglial activation, proliferation, migration, apoptosis and expression of pro-inflammatory cytokines, such as IL6R and CCL3, and the anti-inflammatory cytokine ARG1. Acts as a receptor for lipoprotein particles such as LDL, VLDL, and HDL and for apolipoproteins such as APOA1, APOA2, APOB, APOE, APOE2, APOE3, APOE4, and CLU and enhances their uptake in microglia. Binds phospholipids (preferably anionic lipids) such as phosphatidylserine, phosphatidylethanolamine, phosphatidylglycerol and sphingomyelin. 1. Bouchon, A. et al. (2000) Journal of immunology (Baltimore, Md. : 1950) 164, 4991-5. PMID: 10799849 2. Yeh, FL. et al. (2016) Neuron 91, 328-40. PMID: 27477018 3. Zhao, Y. et al. (2018) Neuron 97, 1023-1031.e7. PMID: 29518356 4. Sudom, A. et al. (2018) The Journal of biological chemistry 293, 12634-12646. PMID: 29794134 5. Kleinberger, G. et al. (2014) Science translational medicine 6, 243ra86. PMID: 24990881 6. Filipello, F. et al. (2018) Immunity 48, 979-991.e8. PMID: 29752066 7. Bouchon, A. et al. (2001) The Journal of experimental medicine 194, 1111-22. PMID: 11602640 8. Paloneva, J. et al. (2003) The Journal of experimental medicine 198, 669-75. PMID: 12925681
Note	For research use only. Not suitable for clinical or therapeutic use.

Images

SDS-PAGE

SDS-PAGE for Research Grade Anti-Human TREM2 Antibody (al002).
SEC-HPLC

SEC-HPLC detection for Research Grade Anti-Human TREM2 Antibody (al002).
Bioactivity

Detects TREM2 in indirect ELISAs.

References

HV166016-SDS-PAGE-1.jpg

Datasheet

Research Grade Anti-Human TREM2 Antibody (al002).pdf

Formula

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Research Grade Anti-Human TREM2 Antibody (al002)