Research Grade Acazicolcept (HY422046)

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100ug
1mg

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Datasheet

Overview

Catalog No.	HY422046
Description	Acazicolcept (HY422046) is a research-grade recombinant antibody targeting CD28. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Functional assay, Research in vivo
Isotype	Fusion - [ICOSLG N-terminal fragment (1-122)]2 - IGHG1 Fc (Fragment constant)
Expression system	Mammalian Cells
Target	CD28, TP44, T-cell-specific surface glycoprotein CD28, CD278, ICOS, Inducible T-cell costimulator, Activation-inducible lymphocyte immunomediatory molecule, AILIM
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P10747 & Q9Y6W8
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Alternate Names	ALPN-101, ICOSLvIgD-Fc, 2270247-50-0
Background	Acazicolcept (ALPN-101), an Fc fusion protein, is a dual inducible T cell costimulator (ICOS)/CD28 antagonist. Acazicolcept has anti-inflammatory activities.
Note	For research use only. Not suitable for clinical or therapeutic use.

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Bioactivity

Detects CD28 in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Research Grade Acazicolcept

References

Datasheet

Research Grade Acazicolcept.pdf

Formula

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Stock Solution

C₁ (Stock Conc.)

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Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Research Grade Acazicolcept (HY422046)

Overview

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References

Datasheet

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