| Catalog No. | HF636016 |
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| Species reactivity | Human |
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| Applications | ELISA, Functional assay, Research in vivo |
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| Isotype | Fusion - FLT1 (fms-related tyrosine kinase 1, vascular endothelial growth factor receptor 1, VEGFR-1, VEGFR, FLT, FRT, vascular permeability factor receptor) domain 2 fragment (14-204) - KDR (kinase insert domain receptor, vascular endothelial growth factor receptor 2, VEGFR2, VEGF-R2, FLK1, CD309) domain 3 fragment (206-308) - IGHG1 Fc (Fragment constant (205-431)) - CR1 (complement receptor type 1, C3b/C4b receptor, C3BR, Knops blood group, KN, CD35) fragment (1-192) |
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| Expression system |
Mammalian Cells |
| Target |
C3, ASP, Complement C3, C3adesArg, C3bc, CPAMD1, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, CO4, Basic complement C4, Complement C4-B, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3, C4B, CPAMD3, Vascular endothelial growth factor A, VPF, VEGFA, VEGF, Vascular permeability factor, VEGF-A |
| Endotoxin level |
Please contact the lab for this information. |
| Purity |
>95% purity as determined by SDS-PAGE. |
| Purification |
Protein A/G purified from cell culture supernatant. |
| Accession |
P01024 & P0C0L5 & P15692 |
| Form |
Liquid |
| Storage buffer |
0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
|
| Stability and Storage |
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Alternate Names | ACVP-1, IBI302, IBI-302, IBI302, 2375661-82-6 |
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| Background | Efdamrofusp alfa is a bispecific fusion protein. Efdamrofusp alfa is capable of neutralizing both VEGF isoforms and C3b/C4b. Efdamrofusp alfa can be used for the research of neovascular age-related macular degeneration (nAMD) and other complement-related ocular conditions.
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| Note |
For research use only. Not suitable for clinical or therapeutic use. |
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