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Research Grade Bedinvetmab (CF909016)

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Research Grade Bedinvetmab

Research Grade Bedinvetmab

Research Grade Bedinvetmab

Research Grade Bedinvetmab

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Spec:

100ug
1mg

Number:

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Overview
Images
References
Datasheet

Overview

Catalog No.	CF909016
Description	Bedinvetmab (CF909016) is a research-grade recombinant antibody targeting NGF/Beta-NGF. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Dog
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Caninized
Isotype	IgG2, lambda
Expression system	Mammalian Cells
Clonality	Monoclonal
Target	NGF/Beta-NGF
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	F1PDQ3
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Alternate Names	ZTS-00508841, 2171034-69-6
Background	Bedinvetmab (ZTS-00508841) is a canine monoclonal antibody (mAb) targeting nerve growth factor (NGF). Bedinvetmab inhibits NGF interaction with tropomyosin receptor kinase A (trkA) and p75 neurotrophin receptor (p75NTR) receptors. Bedinvetmab can be used for the research of osteoarthritis pain in dogs. • Encapsulation of β-NGF in injectable microrods for localized delivery accelerates endochondral fracture repair., PMID:37284244 • New insights of the role of β-NGF in the ovulation mechanism of induced ovulating species., PMID:30763273 • Effect of the Camelid's Seminal Plasma Ovulation-Inducing Factor/β-NGF: A Kisspeptin Target Hypothesis., PMID:28713816 • β-NGF and β-NGF receptor upregulation in blood and synovial fluid in osteoarthritis., PMID:28253191 • The β-NGF/TrkA Signalling Pathway Is Associated With the Production of Anti-Nucleoprotein IgG in Convalescent COVID-19., PMID:35095908 • HDAC6-dependent deacetylation of NGF dictates its ubiquitination and maintains primordial follicle dormancy., PMID:38646645 • Heterologous beta-nerve growth factor (β-NGF) given at the LH surge enhances luteal function in dairy heifers., PMID:34186420 • β-NGF Stimulates Steroidogenic Enzyme and VEGFA Gene Expression, and Progesterone Secretion via ERK 1/2 Pathway in Primary Culture of Llama Granulosa Cells., PMID:33195615 • Ovulation mechanism in South American Camelids: The active role of β-NGF as the chemical signal eliciting ovulation in llamas and alpacas., PMID:32088046 • Astragaloside‑IV modulates NGF‑induced osteoblast differentiation via the GSK3β/β‑catenin signalling pathway., PMID:33179111
Note	For research use only. Not suitable for clinical or therapeutic use.

Images

Bioactivity

Detects Canine NGF in indirect ELISA.
SDS-PAGE

SDS-PAGE for Research Grade Bedinvetmab

References

Datasheet

Research Grade Bedinvetmab.pdf

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Research Grade Bedinvetmab