| Catalog No. | HY106016 |
|---|
| Species reactivity | Human |
|---|
| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
|---|
| Host species | Human |
|---|
| Isotype | IgG1-kappa |
|---|
| Expression system | Mammalian Cells |
|---|
| Clonality | Monoclonal |
|---|
| Target | Complement C2, C2, C3/C5 convertase |
|---|
| Endotoxin level | Please contact the lab for this information. |
|---|
| Purity | >95% purity as determined by SDS-PAGE. |
|---|
| Purification | Protein A/G purified from cell culture supernatant. |
|---|
| Accession | P06681 |
|---|
| Form | Liquid |
|---|
| Storage buffer | 0.01M PBS, pH 7.4. |
|---|
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
|---|
| Alternate Names | 2579031-19-7 |
|---|
| Background | Empasiprubar (ARGX-117) is a humanized inhibitory monoclonal antibody targeting complement C2. Empasiprubar binds to the Sushi-2 domain of C2, preventing the formation of C3 pre convertase and inhibiting the activation of classical and lectin pathways upstream of C3 activation. Empasiprubar can prevent complement mediated autoimmune hemolytic anemia and antibody mediated organ transplant rejection. Empasiprubar can prevent neuroglial lymphoconjunctival injury in GM1 antibody mediated mouse models.
• Granzyme K activates the entire complement cascade., PMID:39914456
• Granzyme K drives a newly-intentified pathway of complement activation., PMID:38826230
• Plasmin as a complement C5 convertase., PMID:27077104
• Inhibition of the alternative C3 convertase and classical C5 convertase of complement by group A streptococcal M protein., PMID:2142480
• Formation of high affinity C5 convertase of the classical pathway of complement., PMID:12878586
• The structure of C2b, a fragment of complement component C2 produced during C3 convertase formation., PMID:19237749
• Modulation of classical C3 convertase of complement by tear lactoferrin., PMID:6922088
• Inhibition of c3 convertase activity by hepatitis C virus as an additional lesion in the regulation of complement components., PMID:24983375
• MASP-2, the C3 convertase generating protease of the MBLectin complement activating pathway., PMID:9777418
• The human complement system: assembly of the classical pathway C3 convertase., PMID:6906228
|
|---|
| Note | For research use only. Not suitable for clinical or therapeutic use. |
|---|
