

| Catalog No. | HB912016 |
|---|---|
| Species reactivity | Human |
| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| Host species | Human |
| Clonality | Monoclonal |
| Isotype | IgG1-kappa |
| Clone ID | Mik beta 1 |
| Expression system | Mammalian cells |
| Target | IL-2R subunit beta, Interleukin-15 receptor subunit beta, IL2RB, IL-2 receptor subunit beta, CD122, High affinity IL-2 receptor subunit beta, p75, Interleukin-2 receptor subunit beta, IL-2RB, p70-75, IL15RB |
| Endotoxin level | < 10 EU/mg |
| Purity | >95% purity as determined by SDS-PAGE. |
| Purification | Protein A/G purified from cell culture supernatant. |
| Accession | P14784 |
| Form | Liquid |
| Storage buffer | 0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Alternate Names | Mik-beta-1, Mikbeta1, Mik-beta1 |
| Background | Interleukin-2 receptor subunit beta (CD122/IL2RB) is a ~61 kDa protein. Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15. 1. Ratthé, C. et al. (2004) Journal of leukocyte biology 76, 162-8. PMID: 15123770 2. Zhang, Z. et al. (2019) The Journal of experimental medicine 216, 1311-1327. PMID: 31040185 |
| References | 1. J Hakimi, et al. Humanized Mik beta 1, a humanized antibody to the IL-2 receptor beta-chain that acts synergistically with humanized anti-TAC. J Immunol. 1993 Jul 15;151(2):1075-85. [HB912016] |
| Note | For research use only. Not suitable for clinical or therapeutic use. |
| Isotype Control | Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507) |

SDS-PAGE for Anti-Human IL-2 R beta Reference Antibody (Mik beta 1, RUO)




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