Anti-Human S100A4 Reference Antibody (AX-202, RUO) (HB727026)

Name: Anti-Human S100A4 Reference Antibody (AX-202, RUO)
Brand: abinScience
SKU: HB727026
Price: 176 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.	HB727026
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG4, kappa
Clone ID	AX-202
Biological activity	AX-202 (8-16 mg/kg, i.p., once every 3 days for 3 weeks; 24 mg/kg, i.v., once weekly for 3 weeks) exhibits antifibrotic and anti-inflammatory effects in a bleomycin ()-induced skin fibrosis model [1].
Expression system	Mammalian cells
Clonality	Monoclonal
Target	S100A4, Protein S100-A4, S100 calcium-binding protein A4, Calvasculin, Protein Mts1, MTS1, CAPL, Placental calcium-binding protein, Metastasin
Endotoxin level	< 10 EU/mg
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P26447
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	AX-202, AX202, CAL101
Background	Protein S100-A4 (S100A4) is a ~11 kDa protein. Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy. Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9. Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis. Also modulates the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels. Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes. 1. Li, ZH. et al. (2006) Cancer research 66, 5173-80. PMID: 16707441 2. Orre, LM. et al. (2013) Oncogene 32, 5531-40. PMID: 23752197 3. Sharapova, TN. et al. (2018) Acta naturae 10, 115-120. PMID: 30713770 4. Dukhanina, EA. et al. (2015) Cell cycle (Georgetown, Tex.) 14, 3635-43. PMID: 26654597
References	1. Trinh-Minh T, et al. Effect of Anti-S100A4 Monoclonal Antibody Treatment on Experimental Skin Fibrosis and Systemic Sclerosis-Specific Transcriptional Signatures in Human Skin. Arthritis Rheumatol. 2024;76(5):783-795. [HB727026]
Note	For research use only. Not suitable for clinical or therapeutic use.

Images

SDS-PAGE

SDS-PAGE for Research Grade Anti-Human S100A4 (AX-202)
Bioactivity

Detects recombinantS100A4 (Catalog No: HB727022) in indirect ELISA.
Western blot

Lane 1: recombinant human S100A4 (Catalog No: HB727022)
Lane 2: 1*loading buffer