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Research Grade Orforglipron (SW328036)

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Overview

Catalog No.	SW328036
Description	Research Grade Orforglipron (SW328036) is a rabbit polyclonal antibody detecting GLP-1 receptor in ELISA, Functional assay, Research in vivo. Suitable for Human. Highlights ●Multi-Application — Validated across multiple applications.
Species reactivity	Human
Applications	ELISA, Functional assay, Research in vivo
Isotype	Biosynthetic GLP-1 analogs.
Species	Human
Target	GLP-1 receptor, Glucagon-like peptide 1 receptor, GLP1R, GLP-1-R, GLP-1R
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by HPLC.
Purification	Purified by HPLC.
Accession	P43220
RRID	Research Grade Orforglipron (abinScience Cat# SW328036, RRID:AB_3729813)
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternate Names	LY3502970, OWL 833, OWL833, OWL-833
Background	Glucagon-like peptide 1 receptor (GLP-1 receptor,Glucagon-like peptide 1 receptor,GLP1R,GLP-1-R,GLP-1R) is a ~53 kDa protein. G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1. 1. Underwood, CR. et al. (2010) The Journal of biological chemistry 285, 723-30. PMID: 19861722 2. Lau, J. et al. (2015) Journal of medicinal chemistry 58, 7370-80. PMID: 26308095 3. Hennen, S. et al. (2016) Scientific reports 6, 26236. PMID: 27196125 4. Song, G. et al. (2017) Nature 546, 312-315. PMID: 28514449 5. van Eyll, B. et al. (1994) FEBS letters 348, 7-13. PMID: 7517895 6. Graziano, MP. et al. (1993) Biochemical and biophysical research communications 196, 141-6. PMID: 8216285 7. Thorens, B. et al. (1993) Diabetes 42, 1678-82. PMID: 8405712
Note	For research use only. Not suitable for clinical or therapeutic use.

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Datasheet

Research Grade Orforglipron.pdf

Formula

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Research Grade Orforglipron