| Catalog No. | MX139016 |
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| Species reactivity | Human |
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| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Host species | Mouse |
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| Isotype | IgG2a-kappa |
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| Expression system | Mammalian Cells |
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| Clonality | Monoclonal |
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| Target | T1, DER4, Interleukin-1 receptor-like 1, ST2, IL1RL1, Protein ST2 |
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| Endotoxin level | Please contact with the lab for this information. |
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| Purity | >95% purity as determined by SDS-PAGE. |
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| Purification | Protein A/G purified from cell culture supernatant. |
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| Accession | Q01638 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS, pH 7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
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| Alternate Names | AMG-282, MSTT-1041A, RG-6149, RO-7187807, 2173054-79-8 |
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| Background | Astegolimab (MSTT 1041A; RG 6149) is a human IgG2 monoclonal antibody that blocks IL-33 signaling by targeting ST2, the IL-33 receptor. Astegolimab has the potential for chronic obstructive pulmonary disease (COPD) research.
• T1/ST2--an IL-1 receptor-like modulator of immune responses., PMID:15110792
• The IL-1 receptor-related T1 antigen is expressed on immature and mature mast cells and on fetal blood mast cell progenitors., PMID:9794420
• Identification of the primary growth response gene, ST2/T1, as a gene whose expression is differentially regulated by different protein kinase C isozymes., PMID:7556667
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| Note | For research use only. |
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