Anti-Human Complement Component C1s Reference Antibody (Claseprubart, RUO) (HY598036)

Name: Anti-Human Complement Component C1s Reference Antibody (Claseprubart, RUO)
Brand: abinScience
SKU: HY598036
Price: 176 USD
Availability: InStock

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Overview

Catalog No.	HY598036
Description	claseprubart (HY598036) is a research-grade recombinant antibody targeting C1S. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG4, Kappa
Species	Human
Clonality	Monoclonal
Target	C1S
Purity	>95% as determined by SDS-PAGE.
Accession	P09871
Form	Liquid
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	2922766-89-8
Background	Complement C1s subcomponent is a ~76 kDa protein. Component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C1S is activated following association of the C1 complex with immunoglobulins (IgG or IgM) complexed with antigens to form antigen-antibody complexes on the surface of pathogens. C1S is cleaved and activated by C1R to generate C1s subcomponent heavy and light chains. C1s subcomponent light chain then cleaves and activates C2 and C4, the next components of the classical complement pathway. 1. Lacroix, M. et al. (2001) The Journal of biological chemistry 276, 36233-40. PMID: 11445589 2. Kerr, FK. et al. (2005) The Journal of biological chemistry 280, 39510-4. PMID: 16169853 3. Kerr, MA. et al. (1978) The Biochemical journal 171, 99-107. PMID: 417728 4. Reboul, A. et al. (1979) FEBS letters 103, 156-61. PMID: 467643 5. McRae, BJ. et al. (1981) The Journal of biological chemistry 256, 12362-6. PMID: 6271784 6. Thielens, NM. et al. (1982) FEBS letters 141, 19-24. PMID: 6282646 7. Thielens, NM. et al. (1984) FEBS letters 165, 111-6. PMID: 6319179 8. Nagasawa, S. et al. (1977) Proceedings of the National Academy of Sciences of the United States of America 74, 2998-3001. PMID: 70787 9. Rossi, V. et al. (1998) The Journal of biological chemistry 273, 1232-9. PMID: 9422791 10. Zwarthoff, SA. et al. (2021) Proceedings of the National Academy of Sciences of the United States of America 118. PMID: 34155115
Note	For research use only. Not suitable for clinical or therapeutic use.