Anti-Human NPRA/NPR1 Reference Antibody (Baloncibart, RUO) (HB010046)

Name: Anti-Human NPRA/NPR1 Reference Antibody (Baloncibart, RUO)
Brand: abinScience
SKU: HB010046
Price: 370 USD
Availability: InStock

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Overview

Catalog No.	HB010046
Description	baloncibart (HB010046) is a research-grade recombinant antibody targeting NPR1/NPR-A. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG4, Kappa
Species	Human
Clonality	Monoclonal
Target	NPR1/NPR-A
Purity	>95% as determined by SDS-PAGE.
Accession	P16066
Form	Liquid
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	2988795-75-9
Background	Atrial natriuretic peptide receptor 1 (NPR1/NPR-A) is a ~118 kDa protein. Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Plays an essential role in the regulation of endothelial cell senescence and vascular aging. Upon activation by ANP or BNP, stimulates the production of cyclic guanosine monophosphate (cGMP) that promotes vascular tone and volume homeostasis by activation of protein kinase cGMP-dependent 1/PRKG1 and subsequently PRKAA1, thereby controlling blood pressure and maintaining cardiovascular homeostasis. 1. Liu, S. et al. (2025) Nature structural & molecular biology 32, 469-478. PMID: 39543315 2. Long, C. et al. (2022) Aging cell 21, e13699. PMID: 36016499
Note	For research use only. Not suitable for clinical or therapeutic use.