Research Grade Clervonafusp Alfa (HY377036)

Name: Research Grade Clervonafusp Alfa
Brand: abinScience
SKU: HY377036
Price: 424 USD
Availability: InStock

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Overview

Catalog No.	HY377036
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Clonality	Monoclonal
Isotype	IgG1-kappa (fused with Homo sapiens GAA/glucosidase alpha)
Biological activity	Lysosomal α-Glucosidase is a γ-amylase that is essential for the degradation of glycogen in lysosomes [1] [2].
Expression system	Mammalian cells
Target	Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter, 36 kDa nucleolar protein HNP36, ENT2, Equilibrative nucleoside transporter 2, SLC29A2, Hydrophobic nucleolar protein, 36 kDa, Equilibrative NBMPR-insensitive nucleoside transporter, Nucleoside transporter, ei-type, Delayed-early response protein 12, Solute carrier family 29 member 2, HNP36, DER12, GAA, Lysosomal alpha-glucosidase, Acid maltase, Aglucosidase alfa
Endotoxin level	< 10 EU/mg
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q14542 & P10253
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	VAL-1221
Background	Clervonafusp alfa (VAL-1221) is a fusion protein targeting both cytosolic and lysosomal glycogen. Clervonafusp alfa is comprised of the Fab portion of a cell-penetrating antibody and recombinant human acid alpha glucosidase (rhGAA), the former utilizing the nucleoside transporter ENT-2 to gain access to the cytosol, and the latter enters lysosomes via mannose-6-phosphate receptors (M6PRs). Clervonafusp alfa can be used for late-onset Pompe disease research.
References	1. Hermans MM, et al. Human lysosomal alpha-glucosidase: functional characterization of the glycosylation sites. The Biochemical journal. 1993 Feb 01;289 (Pt 3)(Pt 3):681-6. [HY377036] 2. Hoefsloot LH, et al. Primary structure and processing of lysosomal alpha-glucosidase; homology with the intestinal sucrase-isomaltase complex. The EMBO journal. 1988 Jun;7(6):1697-704. [HY377036]
Note	For research use only. Not suitable for clinical or therapeutic use.

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Research Grade Clervonafusp Alfa.pdf

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Research Grade Clervonafusp Alfa (HY377036)

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