| Catalog No. | HY112066 |
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| Species reactivity | Human |
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| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Host species | Human |
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| Isotype | IgG2-kappa |
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| Expression system | Mammalian Cells |
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| Clonality | Monoclonal |
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| Target | INSR, IR, CD220, Insulin receptor |
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| Endotoxin level | Please contact the lab for this information. |
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| Purity | >95% purity as determined by SDS-PAGE. |
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| Purification | Protein A/G purified from cell culture supernatant. |
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| Accession | P06213 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS, pH 7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
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| Alternate Names | 2410976-61-1 |
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| Background | Ersodetug is an anti-INSR (insulin receptor) human IgG2 κ monoclonal antibody. Recommend Isotype Controls: Human IgG2 kappa, Isotype Control (HY-P99002).
• Transcriptional Regulation of INSR, the Insulin Receptor Gene., PMID:31795422
• Insulin receptor (IR) and insulin-like growth factor receptor 1 (IGF-1R) signaling systems: novel treatment strategies for cancer., PMID:24338270
• The neuronal insulin receptor in its environment., PMID:27889917
• Insulin receptor orchestrates kidney antibacterial defenses., PMID:38976738
• Activation of the insulin receptor by insulin-like growth factor 2., PMID:38521788
• Alternative splicing of human insulin receptor gene (INSR) in type I and type II skeletal muscle fibers of patients with myotonic dystrophy type 1 and type 2., PMID:23666741
• Analyzing structural differences between insulin receptor (IR) and IGF1R for designing small molecule allosteric inhibitors of IGF1R as novel anti-cancer agents., PMID:32877816
• Homocysteine inhibits pro-insulin receptor cleavage and causes insulin resistance via protein cysteine-homocysteinylation., PMID:34644569
• Insulin Analogues with Altered Insulin Receptor Isoform Binding Specificities and Enhanced Aggregation Stabilities., PMID:34591477
• Deciphering Brain Insulin Receptor and Insulin-Like Growth Factor 1 Receptor Signalling., PMID:27631195
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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