| Catalog No. | HY598026 |
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| Species reactivity | Human |
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| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Host species | Human |
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| Isotype | IgG4-kappa |
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| Expression system | Mammalian Cells |
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| Clonality | Monoclonal |
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| Target | C1 esterase, Complement C1s subcomponent, C1S, Complement component 1 subcomponent s |
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| Endotoxin level | Please contact the lab for this information. |
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| Purity | >95% purity as determined by SDS-PAGE. |
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| Purification | Protein A/G purified from cell culture supernatant. |
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| Accession | P09871 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS, pH 7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
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| Alternate Names | 2756228-76-7 |
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| Background | Riliprubart (SAR445088) is an anti-C1s humanized monoclonal antibody that inhibits activated C1s in the proximal portion of the classical complement system. Riliprubart selectively inhibits activated C1s and prevents the enzymatic action of C1 on its substrates C4 and C2, thus inhibiting the formation of the classical pathway C3 convertase, C4b2a.
• Sutimlimab: First Approval., PMID:35412113
• Complement Component 1, s Subcomponent Overexpression is an Independent Poor Prognostic Indicator in Patients with Urothelial Carcinomas of the Upper Urinary Tract and Urinary Bladder., PMID:27471555
• Genetic studies of low-abundance human plasma proteins. VII. Heterogeneity of the C1S subcomponent of the first complement component., PMID:3331643
• Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation., PMID:23922389
• C1 inhibitor: different mechanisms of reaction with complement component C1 and C1s., PMID:2055603
• Fluid-phase interaction of C1 inhibitor (C1 Inh) and the subcomponents C1r and C1s of the first component of complement, C1., PMID:6282262
• Human complement component C1s. Partial sequence determination of the heavy chain and identification of the peptide bond cleaved during activation., PMID:3007145
• Is there a link between genetic defects in the complement cascade and Porphyromonas gingivalis in Alzheimer's disease?, PMID:31893014
• Periodontal Ehlers-Danlos Syndrome Is Caused by Mutations in C1R and C1S, which Encode Subcomponents C1r and C1s of Complement., PMID:27745832
• Activation of the first component of human complement, C1, by monoclonal antibodies directed against different domains of subcomponent C1q., PMID:3486914
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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