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Research Grade Timdarpacept (HX892106)

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100ug
1mg

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Datasheet

Overview

Catalog No.	HX892106
Species reactivity	Human
Applications	Research Grade Biosimilar
Isotype	Fusion-[human signal-regulatory protein alpha (SIRPα) receptor domain 1 fragment (1-133) natural variant V2 (SIRPα V2)]2-IgG1-Fc (Fragment constant)
Expression system	Mammalian Cells
Clonality	Monoclonal
Target	BIT, Signal-regulatory protein alpha-1, Brain Ig-like molecule with tyrosine-based activation motifs, MFR, SIRP, Sirp-alpha-1, Sirp-alpha-2, PTPNS1, SIRPA, SHP substrate 1, CD172 antigen-like family member A, Sirp-alpha-3, Inhibitory receptor SHPS-1, Signal-regulatory protein alpha-3, CD172a, Tyrosine-protein phosphatase non-receptor type substrate 1, MyD-1 antigen, Bit, SHPS-1, Macrophage fusion receptor, Signal-regulatory protein alpha-2, SHPS1, MYD1, p84
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Purified by nickel column chromatography.
Accession	P78324
Form	Liquid
Storage buffer	0.01M PBS,pH7.4.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Alternate Names	CAS:2749520-17-8
Background	Timdarpacept (DNL310) is a recombinant SIRPa-Fc fusion protein that can activate macrophages to enhance anti-tumor activity by blocking CD47-SIRPa.
Note	For research use only. Not for use in clinical or therapeutic applications.

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References

Datasheet

Research Grade Timdarpacept.pdf

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Research Grade Timdarpacept