Research Grade Anti-Human IL22RA1 Antibody (ARGX-112) (HV951046)

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100ug
1mg

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Overview

Catalog No.	HV951046
Description	Anti-Human IL22RA1 Antibody (ARGX-112) (HV951046) is a research-grade recombinant antibody targeting CRF2-9. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG1
Clone ID	ARGX-112
Expression system	Mammalian Cells
Clonality	Monoclonal
Target	CRF2-9, IL-22RA1, IL22RA1, ZcytoR11, IL-22R-alpha-1, IL-22 receptor subunit alpha-1, Cytokine receptor class-II member 9, Interleukin-22 receptor subunit alpha-1, Cytokine receptor family 2 member 9, IL22R
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q8N6P7
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Alternate Names	ARGX-112, ARGX112, ARGX112
Background	Interleukin-22 receptor subunit alpha-1 (IL22RA1/IL22R) is a ~63 kDa protein. Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.
Note	For research use only. Not suitable for clinical or therapeutic use.