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Research Grade Anti-Human CX3CR1 Antibody (BI 655089) (HW331026)

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Research Grade Anti-Human CX3CR1 Antibody (BI 655089)

Research Grade Anti-Human CX3CR1 Antibody (BI 655089)

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100ug
1mg

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Datasheet

Overview

Catalog No.	HW331026
Description	Anti-Human CX3CR1 Antibody (BI 655089) (HW331026) is a research-grade recombinant antibody targeting CX3CR1. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Isotype	VHH-hFc
Clone ID	BI 655089
Expression system	Mammalian Cells
Clonality	Monoclonal
Target	CX3CR1, Beta chemokine receptor-like 1, Fractalkine receptor, CMK-BRL1, GPR13, CMKBRL1, CX3C chemokine receptor 1, V28, G-protein coupled receptor 13, C-X3-C CKR-1, CMK-BRL-1
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P49238
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Alternate Names	BI655089, BI655089, BI-655089
Background	CX3C chemokine receptor 1 (CX3CR1) is a ~40 kDa protein. Receptor for the C-X3-C chemokine fractalkine (CX3CL1) present on many early leukocyte cells; CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis. CX3CR1-CX3CL1 signaling mediates cell migratory functions. Responsible for the recruitment of natural killer (NK) cells to inflamed tissues. Acts as a regulator of inflammation process leading to atherogenesis by mediating macrophage and monocyte recruitment to inflamed atherosclerotic plaques, promoting cell survival. Involved in airway inflammation by promoting interleukin 2-producing T helper (Th2) cell survival in inflamed lung. 1. Nishimura, M. et al. (2002) Journal of immunology (Baltimore, Md. : 1950) 168, 6173-80. PMID: 12055230 2. Fujita, M. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 189, 5809-19. PMID: 23125415 3. Imai, T. et al. (1997) Cell 91, 521-30. PMID: 9390561 4. Fong, AM. et al. (1998) The Journal of experimental medicine 188, 1413-9. PMID: 9782118 5. Lucas, AD. et al. (2003) Circulation 108, 2498-504. PMID: 14581400 6. Landsman, L. et al. (2009) Blood 113, 963-72. PMID: 18971423 7. Leonardi, I. et al. (2018) Science (New York, N.Y.) 359, 232-236. PMID: 29326275 8. Nakayama, T. et al. (2010) Journal of immunology (Baltimore, Md. : 1950) 185, 6472-9. PMID: 20974991
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE

SDS-PAGE for Research Grade Anti-Human CX3CR1 Antibody (BI 655089).

References

Datasheet

Research Grade Anti-Human CX3CR1 Antibody (BI 655089).pdf

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Research Grade Anti-Human CX3CR1 Antibody (BI 655089)